Fatal outcome of a propoxyphene/acetaminophen (Darvocet) overdose: should it still be used in the United States?
نویسندگان
چکیده
1. Tambourgi DV, Morgan BP, De Andrade RMG, et al. Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis. Blood. 2000;95:683-691. 2. Wasserman GS, Anderson PC. Loxoscelism and necrotic arachnidism. J Toxicol Clin Toxicol. 1983-1984;21:451-472. 3. Loubser PG. Effect of methylprednisolone on complement activation during heparin neutralization. J Cardiovasc Pharmacol. 1997;29:23-27. 4. Hogan CJ, Barbaro KS, Winkle K. Loxoscelism: old obstacles, new directions. Ann Emerg Med. 2004;44:608-624.
منابع مشابه
A difficult balance--pain management, drug safety, and the FDA.
n engl j med 361;22 nejm.org november 26, 2009 2105 conditions, pain is most common ly treated with analgesics. Over the past decade, there have been growing concerns about the harm — abuse and addiction, as well as serious injury and death — caused by the use of prescription and overthecounter analgesics. These concerns have emerged in parallel with the evolving under standing of the impor...
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Propoxyphene and its major metabolite, norpropoxyphene, have been quantitated in tissue specimens obtained from autopsies of people suspected of dying from propoxyphene overdosage. Gas-chromatographic determination of both propoxyphene and norpropoxyphene is essential because the blood concentration of the parent drug should be about 1.0 mg/liter or greater to attribute a death to the drug. The...
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N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
متن کاملN-Acetylcysteine Overdose After Acetaminophen Poisoning
N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
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Acetaminophen is the most commonly used analgesic-antipyretic medication in the United States. Acetaminophen overdose, a frequent cause of drug toxicity, has been recognized as the leading cause of fatal and non-fatal hepatic necrosis. N-Acetylcysteine is the recommended antidote for acetaminophen poisoning. Despite evidence on the efficacy of N-acetylcysteine for prevention of hepatic injury, ...
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ورودعنوان ژورنال:
- Annals of emergency medicine
دوره 57 4 شماره
صفحات -
تاریخ انتشار 2011